Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer.

Aparna ShindeTomasz WilmanskiHao ChenDorothy TeegardenMichael K Wendt

Published in: Breast cancer research : BCR (2018)

Our studies indicate that PC is specifically required for the growth of breast cancer that has disseminated to the lungs. Overall, these findings point to the potential of targeting PC for the treatment of pulmonary metastatic breast cancer.

Keyphrases

metastatic breast cancer
pulmonary hypertension
cancer therapy
combination therapy
climate change
case control
young adults
replacement therapy