Oral Insulin Delay of Stage 3 Type 1 Diabetes Revisited in HLA DR4-DQ8 Participants in the TrialNet Oral Insulin Prevention Trial (TN07).
Lue Ping ZhaoGeorge K PapadopoulosJay S SkylerHemang M ParikhWilliam W KwokGeorge P BondinasAntonis K MoustakasRuihan WangChul-Woo PyoWyatt C NelsonDaniel E GeraghtyLernmark ÅkePublished in: Diabetes care (2024)
These results suggest the presence of a T1D endotype characterized by HLA DR4-DQ8 and/or elevated IA-2A levels; for those patients with stage 1/2 disease with such an endotype, oral insulin delays the clinical T1D onset.