Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms.

Tessa M Kole Simon D PouwelsRene BultsMarlies E KetelaarVictor GuryevLisanne KollHuib A M Kerstjens Martijn C NawijnAlen FaizMaarten van den Berge

Published in: ERJ open research (2023)

Studying the effects of asthma SNPs on alternative splicing can lead to new insights into asthma pathophysiology. More specifically, a 17q12 SNP is associated to alternative splicing of GSDMB . https://bit.ly/3W49oTs.

Keyphrases

chronic obstructive pulmonary disease
lung function
genome wide
allergic rhinitis
cystic fibrosis
high resolution
mass spectrometry