Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia.
Michael J CarterSonu ShresthaPeter O'ReillyPallavi GurungMeeru GurungStephen ThorsonRama KandasamyMerryn VoyseyElizabeth O'MahonySarah KellyImran AnsariGanesh ShahPuja AmatyaIrina TcherniaevaGuy BerbersDavid R MurdochAndrew J PollardShrijana ShresthaDominic F Kellynull nullPublished in: The Pediatric infectious disease journal (2024)
We evaluated whether the quantification of IgG to pneumococcal capsular polysaccharides is an accurate diagnostic test for pneumococcal infection in children with pneumonia in Nepal. Children with pneumococcal pneumonia did not have higher convalescent, or higher fold change, IgG to pneumococcal polysaccharides than children with other causes of pneumonia. Caution is needed in interpreting antibody responses in pneumococcal infections.