Metformin Reduces the Progression of Atherogenesis by Regulating the Sestrin2-mTOR Pathway in Obese and Diabetic Rats.

Saravanakumar Sundararajan Isaivani Jayachandran Gautam Kumar Pandey Saravanakumar Venkatesan Anusha Rajagopal Kuppan Gokulakrishnan Muthuswamy Balasubramanyam Viswanathan Mohan Nagaraj Manickam

Published in: Journal of lipid and atherosclerosis (2023)

This study presents further insights into the beneficial effects of metformin and its protective role against atherosclerosis through regulation of the Sestrin2-AMPK-mTOR pathway.

Keyphrases

diabetic rats
oxidative stress
cell proliferation
adipose tissue
cardiovascular disease
metabolic syndrome
type diabetes
weight loss
skeletal muscle
obese patients