Tacrolimus dose, blood concentrations and acute nephrotoxicity, but not CYP3A5/ABCB1 genetics, are associated with allograft tacrolimus concentrations in renal transplant recipients.

Benedetta C SallustioBenjamin D NollRong HuDaniel T BarrattJonathan TukeJanet K CollerGraeme R RussAndrew Alexander Somogyi

Published in: British journal of clinical pharmacology (2021)

Recipient and donor CYP3A5 and ABCB1 3435C>T genotypes are not determinants of allograft tacrolimus exposure in kidney transplant recipients. However, tacrolimus dose and C0Blood were significant predictors of CGraft , and the relationship between C0Blood and CGraft appeared to differ in the presence or absence of acute nephrotoxicity.

Keyphrases

drug induced
liver failure
respiratory failure
aortic dissection
intensive care unit