Mapping the Single-Cell Differentiation Landscape of Osteosarcoma.

Danh D Truong Corey Weistuch Kevin A Murgas Prasad Admane Bridgette L King Jes Chauviere Lee Salah-Eddine Lamhamedi-Cherradi Jyothishmathi Swaminathan Najat C Daw Nancy Gordon Vidya Gopalakrishnan Richard G Gorlick Neeta Somaiah Joseph O Deasy Antonios G Mikos Allen R Tannenbaum Joseph A Ludwig

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our study quantifies osteosarcoma differentiation and lineage, a prerequisite to better understanding lineage-specific differentiation bottlenecks that might someday be targeted therapeutically.

Keyphrases

single cell
rna seq
high throughput
high resolution
cell fate