Resident Synovial Macrophages in Synovial Fluid: Implications for Immunoregulation in Infectious and Inflammatory Arthritis.
Karen I CyndariBreanna M ScorzaZeb R ZachariasLeela StrandKurayi MahachiJuan Marcos OviedoLisa GibbsDanielle Pessoa-PereiraGraham AusdalDylan HendricksRika YahashiriJacob M ElkinsTrevor GulbrandsenAndrew R PetersonMichael C WilleyKeke C FairfaxChristine A PetersenPublished in: bioRxiv : the preprint server for biology (2023)
We identified a rare cell population consistent with RSM, indicating these cells are likely migratory and able to initiate or coordinate both acute (septic) or chronic (autoimmune or inflammatory) arthritis. RSM analysis via scRNA-seq indicated these cells are M2 skewed, capable of antigen presentation, and have consistent functions in both septic and inflammatory arthritis.
Keyphrases
- induced apoptosis
- rheumatoid arthritis
- oxidative stress
- cell cycle arrest
- single cell
- acute kidney injury
- multiple sclerosis
- drug induced
- cell death
- signaling pathway
- stem cells
- cell proliferation
- genome wide
- dna methylation
- patient safety
- gene expression
- hepatitis b virus
- case report
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- data analysis