Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes.
Christoph M MooshageDimitrios TsilingirisLukas SchimpfleZoltan KenderTaraneh Aziz-SafaieAnja HohmannJulia SzendroediPeter NawrothVolker SturmSabine HeilandMartin BendszusStefan KopfFelix T KurzJohann Malte Enno JendePublished in: The Journal of clinical endocrinology and metabolism (2023)
The results signify that skeletal muscle DCE MRI can be employed as a non-invasive technique for the assessment of muscles' microcirculation in T2D. Our findings suggest that microvascular permeability of skeletal muscle is lowered in patients with T2D and that a decrease in microvascular permeability is associated with insulin resistance. These results are of interest with regards to the impact of muscle perfusion on diabetic complications such as diabetic sarcopenia.
Keyphrases
- skeletal muscle
- insulin resistance
- contrast enhanced
- high fat diet
- type diabetes
- endothelial cells
- polycystic ovary syndrome
- wound healing
- high fat diet induced
- magnetic resonance imaging
- adipose tissue
- metabolic syndrome
- magnetic resonance
- risk factors
- glycemic control
- diffusion weighted imaging
- weight loss
- clinical evaluation