LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells.

Francesca De Faveri Michael Chvanov Svetlana Voronina Danielle Moore Liam Pollock Lee Haynes Muhammad Awais Alison J Beckett Ulrike Mayer Robert Sutton David N Criddle Ian A Prior Thomas Wileman Alexei V Tepikin

Published in: Autophagy (2019)

AP: acute pancreatitis; CCK: cholecystokinin; CLEM: correlative light and electron microscopy; DPI: diphenyleneiodonium; EV: endocytic vacuole; LAP: LC3-associate phagocytosis; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; PACs: pancreatic acinar cells; PFA: paraformaldehyde; PtdIns3K: phosphatidylinositol 3-kinase; PtdIns3P: phosphatidylinositol 3-phosphate; Res: resveratrol; TAP: trypsinogen activation peptide; TEM: transmission electron microscopy; TLC-S: taurolithocholic acid 3-sulfate; TRD: Dextran Texas Red 3000 MW Neutral; ZGs: zymogen granules.

Keyphrases

electron microscopy
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
simultaneous determination
cell death
protein kinase
signaling pathway
oxidative stress
mass spectrometry
liquid chromatography
transcription factor
pi k akt
tandem mass spectrometry