Brain hypometabolism in non-demented microtubule-associated protein tau H1 carriers with Parkinson's disease.
Carmen Gasca-SalasClara TrompetaMiguel López-AguirreRafael Rodríguez RojasJordi ClarimonOriol Dols-IcardoShaimaa El BounasriPasqualina GuidaDavid Mata-MarínFrida Hernández-FernándezConnie MarrasLina García-CañamaqueIsabel Plaza de Las HerasIgnacio ObesoLydia VelaBeatriz Fernández-RodríguezPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2023)
PD patients MAPT H1/H1 carriers without dementia exhibit relative hypometabolism in several cortical areas as well as in the basal ganglia, and worse performance in attention than MAPT H1/H2 carriers. Longitudinal studies should assess if lower scores in attention and dysfunction in these areas are predictors of dementia in MAPT H1/H1 homozygotes.