Visual acuity and progression of macular atrophy in patients receiving intravitreal anti-VEGF for age-related macular degeneration.
Marco H JiNatalia F CallawayCassie A LudwigDaniel VailAhmad Al-MoujahedTatiana R RosenblattTheodore LengSteven R SanisloDarius M MoshfeghiPublished in: European journal of ophthalmology (2021)
The discrepancy between structural and functional findings in this cohort suggests that patients treated by anti-VEGF drugs exhibit divergent clinical outcomes for currently unknown reasons. The authors propose anti-VEGF may affect melanosomes within RPE without disrupting RPE and photoreceptors function completely. This requires further investigation.