Imbalance of early-life vitamin D intake targets ROS-mediated crosstalk between mitochondrial dysfunction and differentiation potential of MSCs associated the later obesity.
Ping LiYang WangYueqing LiangXueyi JiangTiantian TangXiuqin FanRui WangMengyi YangYuanlin LiuKemin QiYi ZhangPublished in: Stem cell research & therapy (2024)
These findings demonstrated that imbalance of early-life VD intake could target ROS-mediated crosstalk between mitochondrial dysfunction and differentiation potential of MSCs, which was significantly associated with the later obesity. Obviously, our results could open up an attractive modality for the benefits of suitable VD intake during the pregnancy and lactation.
Keyphrases
- early life
- weight gain
- insulin resistance
- metabolic syndrome
- mesenchymal stem cells
- weight loss
- type diabetes
- cell death
- dna damage
- high fat diet induced
- reactive oxygen species
- body mass index
- umbilical cord
- human health
- minimally invasive
- preterm birth
- human milk
- risk assessment
- pregnancy outcomes
- dairy cows
- skeletal muscle
- bone marrow
- climate change