Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy.
Zhipeng HongTao LiuLingfeng WanPengyan FaPankaj KumarYanan CaoChandra Bhushan PrasadZhaojun QiuJoseph LiuHongbing WangZaibo LiHongbing WangPeixuan GuoDeliang GuoAyse S YilmazLanchun LuIoanna PapandreouNaduparambil K JacobChunhong YanXiaoli ZhangQing-Bai SheZhefu MaJunran ZhangPublished in: Cancer research (2022)
Squalene epoxidase inhibitors are novel tumor-specific radiosensitizers that promote ER stress and suppress homologous recombination, providing a new potential therapeutic approach to enhance radiotherapy efficacy.