Association of ACE I/D gene polymorphism and related risk factors in impaired fasting glucose and type 2 diabetes: a study among two tribal populations of North-East India.
Sunanda RajkumariSomorjit Singh NingombamVarhlun ChhungiMasan Kambo NewmeiNaorem Kiranmala DeviPrakash Ranjan MondalKallur Nava SaraswathyPublished in: Molecular biology reports (2021)
The present study is an example of gene-environment interaction where DD genotype or D allele and dyslipidemia (high TC and high LDL) are posing risk for IFG and T2D both independently and in combination only among Mizo tribe with relatively less physical activity attributed to their residence in less hilly terrain however Liangmai tribe which resides in high hilly terrain shows no such association.
Keyphrases
- type diabetes
- risk factors
- physical activity
- insulin resistance
- blood glucose
- body mass index
- cardiovascular disease
- genome wide
- adipose tissue
- dna methylation
- blood pressure
- copy number
- skeletal muscle
- depressive symptoms
- tertiary care
- transcription factor
- genetic diversity
- sleep quality
- drug induced
- low density lipoprotein