Antagonizing EZH2 combined with vitamin D3 exerts a synergistic role in anti-fibrosis through bidirectional effects on hepatocytes and hepatic stellate cells.

Qinghui ZhangRongrong JiaMinjie ChenJianjun WangFeng HuangMin ShiHuiming ShengLing Xu

Published in: Journal of gastroenterology and hepatology (2023)

Vitamin D3 is responsible for the anti-fibrosis, which might have bidirectional effects on HSCs by regulating histone modification. The inhibitor of Ezh2 plays a synergistic role in this process.

Keyphrases

induced apoptosis
long non coding rna
long noncoding rna
dna methylation
cell cycle arrest
oxidative stress
liver fibrosis
drug delivery
cell proliferation
cell death