Discovery of circulating blood biomarkers in patients with and without Modic changes of the lumbar spine: a preliminary analysis.
Khaled AboushaalaAna V CheeSheila J ToroRajko VucicevicCatherine YuhJake DourdourekasIshani K PatelAlejandro Espinoza-OriasChundo OhLena Al-HarthiJaro KarppinenEdward J GoldbergFrank M PhillipsMatthew ColmanFrances M K WilliamsJeffrey A BorgiaStefan GreenChristopher ForsythHoward S AnDino SamartzisPublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2024)
This "proof-of-concept" study is the first to identify specific and significantly circulating blood biomarkers associated with symptomatic patients with lumbar MC, independent of disc alterations of degeneration and/or bulges/herniations. Specifically, differences in CCL5 and MIF protein levels were significantly noted in MC patients compared to those without MC.