FDG-PET in Chimeric Antigen Receptor T-Cell (CAR T-Cell) Therapy Toxicity: A Systematic Review.
Akram N Al-IbraheemAhmed Saad AbdlkadirEgesta LopciSudqi AllouziDiana PaezMaryam AlkuwariMohammad Ma'kosehFuad NovruzovSharjeel UsmaniKamal Al-RabiAsem H MansourPublished in: Cancers (2024)
The utilization of chimeric antigen receptor (CAR) T-cell therapy to target cluster of differentiation (CD)19 in cancer immunotherapy has been a recent and significant advancement. Although this approach is highly specific and selective, it is not without complications. Therefore, a systematic review was conducted to assess the current state of positron emission tomography (PET) in evaluating the adverse effects induced by CAR T-cell therapy. A thorough search of relevant articles was performed in databases such as PubMed, Scopus, and Web of Science up until March 2024. Two reviewers independently selected articles and extracted data, which was then organized and categorized using Microsoft Excel. The risk of bias and methodological quality was assessed. In total, 18 articles were examined, involving a total of 753 patients, in this study. A wide range of utilities were analyzed, including predictive, correlative, and diagnostic utilities. While positive outcomes were observed in all the mentioned areas, quantitative analysis of the included studies was hindered by their heterogeneity and use of varying PET-derived parameters. This study offers a pioneering exploration of this promising field, with the goal of encouraging further and more focused research in upcoming clinical trials.
Keyphrases
- cell therapy
- positron emission tomography
- computed tomography
- pet ct
- pet imaging
- stem cells
- mesenchymal stem cells
- clinical trial
- end stage renal disease
- chronic kidney disease
- public health
- high resolution
- big data
- oxidative stress
- ejection fraction
- machine learning
- patient reported outcomes
- newly diagnosed
- risk factors
- type diabetes
- metabolic syndrome
- electronic health record
- prognostic factors
- data analysis
- weight loss
- nk cells