Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka during a dengue-1 epidemic.
Champica K BodinayakeL Gayani TillekeratneAjith NagahawatteVasantha DevasiriWasantha Kodikara ArachchiJohn J StrouseOctober M SessionsRuvini KurukulasooriyaAnna UeharaShiqin HoweXin Mei OngSharon TanAngelia ChowPraveen TummalapalliAruna D De SilvaTruls ØstbyeChristopher W WoodsDuane J GublerMegan E RellerPublished in: PLoS neglected tropical diseases (2018)
In a large cohort with AFI, we identified features predictive of dengue vs other AFI and secondary vs primary dengue in adults versus children. The 2009 WHO dengue classification criteria had high sensitivity but low specificity compared to physicians' gestaldt diagnosis. Large cohort studies will be needed to validate the diagnostic yield of clinical impression and specific features for dengue relative to the 2009 WHO classification criteria.