Acute nicotine vapor normalizes sensorimotor gating and reduces locomotor activity deficits in HIV-1 transgenic rats.
Neal A JhaSamantha M AyoubM Melissa FlesherKathleen MortonMegan SikkinkGiordano de GuglielmoJibran Younis KhokharArpi MinassianArthur L BrodyJared W YoungPublished in: bioRxiv : the preprint server for biology (2024)
Previous findings of PPI deficits in HIV-1Tg rats were replicated and, importantly, attenuated by acute nicotine vapor. Evidence for similar cotinine levels suggest a nicotine-specific effect in HIV-1Tg rats. HIV-1Tg rats had reduced exploratory behavior compared to controls, attenuated by acute nicotine vapor. Therefore, acute nicotine may be beneficial for remediating sensorimotor and locomotor activity deficits in PWH. Future studies should determine the long-term effects of nicotine vapor on similar HIV/NCI-relevant behaviors.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- smoking cessation
- liver failure
- hepatitis c virus
- hiv aids
- men who have sex with men
- respiratory failure
- traumatic brain injury
- spinal cord injury
- drug induced
- aortic dissection
- south africa
- functional connectivity
- extracorporeal membrane oxygenation