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LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway.

Bing LiuShimeng PanYang XiaoQianqian LiuJingchao XuLi Jia
Published in: Journal of experimental & clinical cancer research : CR (2018)
These new findings indicate that linc01296/miR-26a/GALNT3 axis involves in the progression of CRC cells, illuminating the possible mechanism mediated by O-glycosylated MUC1 via PI3K/AKT pathway. This work renders potential diagnostic biomarkers and prospective therapeutic targets for CRC.
Keyphrases
  • long non coding rna
  • long noncoding rna
  • cell proliferation
  • induced apoptosis
  • cell cycle arrest
  • pi k akt
  • signaling pathway
  • oxidative stress
  • cell death