LINC01296/miR-26a/GALNT3 axis contributes to colorectal cancer progression by regulating O-glycosylated MUC1 via PI3K/AKT pathway.

Bing LiuShimeng PanYang XiaoQianqian LiuJingchao XuLi Jia

Published in: Journal of experimental & clinical cancer research : CR (2018)

These new findings indicate that linc01296/miR-26a/GALNT3 axis involves in the progression of CRC cells, illuminating the possible mechanism mediated by O-glycosylated MUC1 via PI3K/AKT pathway. This work renders potential diagnostic biomarkers and prospective therapeutic targets for CRC.

Keyphrases

long non coding rna
long noncoding rna
cell proliferation
induced apoptosis
cell cycle arrest
pi k akt
signaling pathway
oxidative stress
cell death