Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium.
Caitlin G HoweBianca CoxRuby ForeJames JungiusTuomas KvistSamantha LentHarriet E MilesLucas A SalasSheryl Rifas-ShimanAnne P StarlingPaul YousefiChristine Ladd-AcostaAndrea BaccarelliElisabeth B BinderVaia Lida ChatziDarina CzamaraDana M DabeleaDawn L DeMeoAkram GhantousZdenko HercegEero KajantieJari M T LahtiDeborah A LawlorAugusto LitonjuaTim S NawrotEllen A NohrEmily OkenCostanza PizziMichelle PlusquinKatri RäikkönenCaroline L ReltonGemma C SharpThorkild I A SørensenJordi SunyerMartine VrijheidWeiming ZhangMarie-France HivertCarrie V BretonPublished in: Diabetes care (2019)
Maternal GDM was associated with lower cord blood methylation levels within two regions, including the promoter of OR2L13, a gene associated with autism spectrum disorder, and the gene body of CYP2E1, which is upregulated in type 1 and type 2 diabetes. Future studies are needed to understand whether these associations are causal and possible health consequences.
Keyphrases
- dna methylation
- genome wide
- pregnancy outcomes
- cord blood
- type diabetes
- copy number
- gene expression
- pregnant women
- birth weight
- public health
- healthcare
- genome wide identification
- preterm birth
- mental health
- current status
- transcription factor
- cardiovascular disease
- glycemic control
- health information
- body mass index
- metabolic syndrome
- climate change
- health promotion
- skeletal muscle
- weight gain
- case control
- childhood cancer