Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms.
Ben MaElaina MeltonRobert WienerNing ZhouWenqian WuLo LaiCharles WangKevin D CostaHongyu QiuPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
Our results indicate distinct mechanisms mediating aging-associated aortic VSMC and vessel stiffness, providing new insights into aortic stiffening and the pathogenesis of hypertension in the elderly.