Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin-10 in Murine Models.

Eiji YubaErica BudinaKiyomitsu KatsumataAko IshiharaAslan MansurovAaron T AlparElyse A WatkinsPeyman HosseinchiJoseph W RedaAbigail L LauterbachMindy NguyenAni SolankiTakahiro KageyamaMelody A SwartzJun IshiharaJeffrey A Hubbell

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

SA fusion to IL-10 is a simple but effective engineering strategy for RA therapy and has potential for clinical translation.

Keyphrases

rheumatoid arthritis
lymph node
disease activity
ankylosing spondylitis
interstitial lung disease
neoadjuvant chemotherapy
sentinel lymph node
squamous cell carcinoma
systemic sclerosis
risk assessment
climate change
idiopathic pulmonary fibrosis
replacement therapy
smoking cessation