The ADAMTS13-von Willebrand factor axis in COVID-19 patients.
Illaria ManciniLuciano BaroncianiAndrea ArtoniPaola ColpaniMarina BiganzoliGiovanna CozziCristina NovembrinoMassimo Boscolo AnzolettiValentina De ZanMaria Teresa PagliariRoberta GualtierottiStefano AlibertiMauro PanigadaGiacomo GrasselliFrancesco BlasiFlora PeyvandiPublished in: Journal of thrombosis and haemostasis : JTH (2020)
We found a significant alteration of the VWF-ADAMTS13 axis in COVID-19 patients, with an elevated VWF:Ag to ADAMTS13 activity ratio that was strongly associated with disease severity. Such an imbalance enhances the hypercoagulable state of COVID-19 patients and their risk of microthrombosis.