Management of anaphylaxis due to COVID-19 vaccines in the elderly.
Jean BousquetIoana AgacheHubert BlainMarek JutelMaria Teresa VenturaMargitta WormStefano Del GiaccoAthanasios BenetosBeatrice Maria BiloWienczyslawa CzarlewskiAmir Hamzah Abdul LatiffMona Al-AhmadElizabeth AngierIsabella Annesi-MaesanoMarina Atanaskovic-MarkovicClaus BachertAnnick BarbaudAnna BedbrookKazi S BennoorElena Camelia BergheaCarsten Bindslev-JensenSergio BoniniSinthia Bosnic-AnticevichKnut BrockowLuisa BrussinoPaulo CamargosGiorgio Walter CanonicaVictoria CardonaPedro Carreiro-MartinsAna CarriazoThomas CasaleJean-Christoph CaubetLorenzo CecchiAntonio CherubiniGeorge ChristoffDerek K ChuÁlvaro Augusto CruzDejan DokicYehia El-GamalMotohiro EbisawaBernadette EberleinJohn FarrellMontserrat Fernandez-RivasWytske J FokkensJoao A FonsecaYadong GaoGaëtan GavazziRadoslaw GawlikAslı GelincikBilun GemicioğluMaia GotuaOlivier GuérinTari HaahtelaKarin Hoffmann-SommergruberHans Jürgen HoffmannMaja HofmannMartin HrubiskoMaddalena IllarioCarla IraniZhanat IspayevaJuan Carlos IvancevichKaja JulgeIgor KaidashevKhaitov M REdward KnolHelga KraxnerPiotr KunaVioleta KvedarieneAntti LauermaLan T T LeVincent Le MoingMichael Eliad LevinRenaud LouisOlga M LourençoVera MahlerFinbarr C MartinAndrea MatucciBranislava MilenkovicStéphanie MiotEmma MontellaMario Morais-AlmeidaCharlotte Gotthard MortzJoaquim MullolLeyla Namazova-BaranovaHugo NeffenKristof NekamMarek NiedoszytkoMikaëla OdemyrRobyn Elizabeth O'HehirYoshitaka OkamotoMarkus OllertÓscar PalomaresPapadopoulos G NikolaosPetr PanznerGiovanni PassalacquaVincenzo PatellaMirko PetrovicOliver PfaarNhân Pham-ThiDavor PlavecTodor A PopovMarysia T RectoFrederico S RegateiroJacques ReynesRegina E Roller-WinsbergerYves RollandAntonino RomanoCarmen RondónMenachem RottemPhilip W RouadiNathalie SallesBoleslaw SamolinskiAlexandra F SantosFaradiba S SarquisJoaquin SastreJos M G A ScholsNicola ScichiloneAnna SedivaM H Mohamed ShamjiAziz SheikhIsabel J SkypalaSylwia SmolinskaMilena SokolowskaBernardo Sousa-PintoMilan SovaRafael StelmachGunter SturmCharlotte Suppli UlrikAna Maria Todo-BomSanna Toppila-SalmiIoanna TsiligianniTorres María JoséEva UntersmayrMarilyn Urrutia PereiraArunas ValiulisJoana VitteAlessandra VultaggioDana WallaceJolanta Walusiak-SkorupaDe-Yun WangSusan WasermanArzu YorganciogluOsman M YusufMario ZernottiMihaela ZidarnTomás ChivatoMübeccel AkdisTorsten ZuberbierLudger KlimekPublished in: Allergy (2021)
Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.
Keyphrases
- coronavirus disease
- sars cov
- physical activity
- allergic rhinitis
- respiratory syndrome coronavirus
- blood pressure
- metabolic syndrome
- chronic obstructive pulmonary disease
- early onset
- insulin resistance
- weight loss
- lung function
- cystic fibrosis
- weight gain
- adipose tissue
- air pollution
- clinical practice
- combination therapy
- infectious diseases