Is leptin resistance the cause or the consequence of diet-induced obesity?

Kathy C G de GitCéline PeterseSanne BeerensMieneke C M LuijendijkGeoffrey van der PlasseSusanne E la Fleur Roger A H Adan

Published in: International journal of obesity (2005) (2018)

A pre-existing reduction in leptin sensitivity determines the susceptibility to develop excessive DIO after fcHFHS diet exposure. Rats with a pre-existing reduction in leptin sensitivity develop excessive DIO without eating more calories or altering their leptin sensitivity.

Keyphrases

weight loss
weight gain
physical activity
metabolic syndrome
type diabetes
insulin resistance
body mass index