Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4/NFκB/NLRP3 signaling pathway in cerebral ischemic mice.
Lu LuoMeixi LiuYunhui FanJingjun ZhangLi LiuYun LiQiqi ZhangHongyu XieCongyu JiangJunfa WuXiao XiaoYi WuPublished in: Journal of neuroinflammation (2022)
rTMS could alleviate cerebral I/R injury induced locomotor deficits and neuronal pyroptosis by modulating the microglial polarization. It is expected that these data will provide novel insights into the mechanisms of rTMS protecting against cerebral I/R injury and potential targets underlying neuronal pyroptosis in the early phase of stroke.
Keyphrases
- cerebral ischemia
- signaling pathway
- subarachnoid hemorrhage
- nlrp inflammasome
- transcranial magnetic stimulation
- inflammatory response
- brain injury
- lps induced
- blood brain barrier
- high frequency
- pi k akt
- lipopolysaccharide induced
- epithelial mesenchymal transition
- induced apoptosis
- toll like receptor
- neuropathic pain
- spinal cord injury
- electronic health record
- immune response
- nuclear factor
- atrial fibrillation
- high glucose
- drug induced
- high intensity
- adipose tissue
- metabolic syndrome
- cell proliferation
- artificial intelligence
- big data
- human health