Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences.

Dawit A YohannesKatri KaukinenKalle KurppaPäivi SaavalainenDario Greco

Published in: BMC bioinformatics (2021)

We conclude that immune sub-repertoires of similar immuno-genomic features shared across unrelated individuals can serve as viable units of immune repertoire comparison, serving as proxy for identification of condition-associated CDR3s.

Keyphrases

bioinformatics analysis
single cell
cord blood
high throughput sequencing
clinical evaluation