Measuring What Is Meaningful in Cancer Cachexia Clinical Trials: A Path Forward With Digital Measures of Real-World Physical Behavior.
Suvekshya AryalShelby L BachmanKate LydenIeuan ClayPublished in: JCO clinical cancer informatics (2023)
Digital measures of real-world physical behavior present an opportunity to detect and demonstrate improvements in physical functioning in cancer cachexia, but evidence-based development is critical. For their use in clinical and regulatory decision making, studies demonstrating meaningfulness to patients as well as feasibility and validation are necessary.
Keyphrases
- papillary thyroid
- physical activity
- clinical trial
- mental health
- end stage renal disease
- decision making
- squamous cell
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- transcription factor
- squamous cell carcinoma
- patient reported outcomes
- young adults
- case control
- patient reported
- double blind