A Counting Stroop Functional Magnetic Resonance Imaging Study on the Effects of ORADUR-Methylphenidate in Drug-Naive Children with Attention-Deficit/Hyperactivity Disorder.
Chi-Yung ShangTai-Li ChouCheng-Yu HsiehSusan Shur-Fen GauPublished in: Journal of child and adolescent psychopharmacology (2022)
<b><i>Objective:</i></b> Methylphenidate is effective in reducing the clinical symptoms of patients with attention-deficit/hyperactivity disorder (ADHD). ORADUR<sup>®</sup>-methylphenidate is a new extended-release preparation of methylphenidate. This study aimed at identifying brain regions with activation changes and their correlations with neuropsychological functions after treatment with ORADUR-methylphenidate in children with ADHD. <b><i>Methods:</i></b> We recruited drug-naive children with ADHD and age- and sex-matched typically developing (TD) children. They were all scanned with the functional magnetic resonance imaging (fMRI) during the counting Stroop task at baseline, and those with ADHD had the second fMRI assessment after 8-week treatment with ORADUR-methylphenidate. The Rapid Visual Information Processing (RVP) and Conners' Continuous Performance Test (CCPT) were used to assess the attention performance of the ADHD (before and after treatment) and TD groups. <b><i>Results:</i></b> ORADUR-methylphenidate significantly decreased inattention (Cohen <i>d</i> = 2.17) and hyperactivity-impulsivity (Cohen <i>d</i> = 0.98) symptoms. We found less activation in the right inferior frontal gyrus (rIFG) in the pre-treatment ADHD children than TD children and greater treatment-induced activation in the dorsal anterior cingulate cortex (dACC) and the right dorsolateral prefrontal cortex (rDLPFC). There was no significant difference between the post-treatment ADHD and TD groups. However, the treatment-related activations in the dACC, rDLPFC, and rIFG were significantly correlated with CCPT and RVP measures. <b><i>Conclusions:</i></b> Our findings indicated that ORADUR-methylphenidate increased brain activations in the dACC, rDLPFC, and rIFG in children with ADHD, associated with improved focused attention, reduced impulsivity, and enhanced inhibition control. Activities of these brain regions might be biomarkers for the treatment effectiveness of methylphenidate for ADHD. <b><i>Clinical Trials Registration:</i></b> ClinicalTrials.gov number, NCT02450890.
Keyphrases
- attention deficit hyperactivity disorder
- working memory
- autism spectrum disorder
- magnetic resonance imaging
- young adults
- clinical trial
- computed tomography
- functional connectivity
- systematic review
- combination therapy
- healthcare
- prefrontal cortex
- oxidative stress
- end stage renal disease
- spinal cord
- peritoneal dialysis
- physical activity
- high frequency
- brain injury
- social media
- electronic health record
- transcranial magnetic stimulation
- contrast enhanced
- white matter
- newly diagnosed
- diabetic rats
- deep brain stimulation
- phase iii
- patient reported outcomes