Smart Polymeric Micelles for Anticancer Hydrophobic Drugs.
Andy Guzmán RodríguezMarquiza Sablón CarrazanaChrislayne Rodríguez TantyMartijn J A MalessyGastón FuentesLuis J CruzPublished in: Cancers (2022)
Cancer has become one of the deadliest diseases in our society. Surgery accompanied by subsequent chemotherapy is the treatment most used to prolong or save the patient's life. Still, it carries secondary risks such as infections and thrombosis and causes cytotoxic effects in healthy tissues. Using nanocarriers such as smart polymer micelles is a promising alternative to avoid or minimize these problems. These nanostructured systems will be able to encapsulate hydrophilic and hydrophobic drugs through modified copolymers with various functional groups such as carboxyls, amines, hydroxyls, etc. The release of the drug occurs due to the structural degradation of these copolymers when they are subjected to endogenous (pH, redox reactions, and enzymatic activity) and exogenous (temperature, ultrasound, light, magnetic and electric field) stimuli. We did a systematic review of the efficacy of smart polymeric micelles as nanocarriers for anticancer drugs (doxorubicin, paclitaxel, docetaxel, lapatinib, cisplatin, adriamycin, and curcumin). For this reason, we evaluate the influence of the synthesis methods and the physicochemical properties of these systems that subsequently allow an effective encapsulation and release of the drug. On the other hand, we demonstrate how computational chemistry will enable us to guide and optimize the design of these micelles to carry out better experimental work.
Keyphrases
- drug delivery
- drug release
- cancer therapy
- drug induced
- minimally invasive
- mental health
- locally advanced
- ionic liquid
- magnetic resonance imaging
- papillary thyroid
- gene expression
- emergency department
- squamous cell carcinoma
- hydrogen peroxide
- acute coronary syndrome
- human health
- computed tomography
- rectal cancer
- ultrasound guided
- positive breast cancer
- coronary artery disease
- hyaluronic acid
- aqueous solution
- combination therapy
- surgical site infection
- tandem mass spectrometry