TDP-43 Proteinopathy Presenting with Typical Symptoms of Parkinson's Disease.

Rika Yamashita Goichi BeckYuki YonenobuKimiko InoueAkihiko MitsutakeHiroyuki IshiuraMasato HasegawaShigeo MurayamaHideki Mochizuki

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

Accumulation of abnormal transactivation response DNA-binding protein of 43 kDa (TDP-43) independently induces dopaminergic neuronal loss in the substantia nigra without Lewy pathology, and results in typical Parkinson's disease-like motor symptoms.

Keyphrases

binding protein
amyotrophic lateral sclerosis
circulating tumor
sleep quality
single molecule
cell free
physical activity
brain injury
subarachnoid hemorrhage