Cyclin-dependent kinase 1 targeting improves sensitivity to radiation in BRAF V600E colorectal carcinoma cells.

Girolamo SpagnolettiValeria Li BergolisAnnamaria PiscazziFrancesca GiannelliValentina CondelliLorenza SisinniGiuseppe BoveGiovanni StortoMatteo Landriscina

Published in: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (2018)

These data suggest that BRAF V600E colorectal carcinoma cells are poorly responsive to radiation, and cyclin-dependent kinase 1 represents a target to improve radiosensitivity in BRAF V600E colorectal tumor cells.

Keyphrases

metastatic colorectal cancer
cell cycle
wild type
cancer therapy
protein kinase
tyrosine kinase
electronic health record
drug delivery
machine learning
cell proliferation
radiation therapy
cell death