Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage.
Maria ErcuMichael B MückeTamara PallienLajos MarkóAnastasiia SholokhCarolin SchächterleAtakan AydinAlexa KiddStephan WalterYasmin EsmatiBrandon J McMurrayDaniella F LatoDaniele Yumi Sunaga-FranzePhilip H DierksBarbara Isabel Montesinos FloresRyan Walker-GrayMaolian GongClaudia MerticariuKerstin ZühlkeMichael RusswurmTiannan LiuTheda Ulrike Patricia BartolomaeusSabine PautzStefanie SchelenzMartin TaubeHanna NapieczynskaArnd HeuserJenny EichhorstMartin LehmannDuncan C MillerSebastian DieckeFatimunnisa QadriElena PopovaReika LangankiMatthew A MovsesianFriedrich W HerbergSofia K ForslundDominik N MullerTatiana BorodinaPhilipp G MaassSylvia BähringNorbert HübnerMichael BaderAnastasiia SholokhPublished in: Circulation (2022)
mutations in the heart rather than nonselective PDE3 inhibition is cardioprotective in the long term. Our findings could facilitate the search for new treatments to prevent hypertension-induced cardiac damage.