UBQLN1 links proteostasis and mitochondria function to telomere maintenance in human embryonic stem cells.

Shuang ZhaoJie LiSongqi DuanChang LiuHua WangJiangtao LuNannan ZhaoXiaoyan ShengYiwei WuYanjun LiBaofa SunLin Liu

Published in: Stem cell research & therapy (2024)

Altogether, UBQLN1 functions to scavenge ubiquitinated proteins, preventing their overloading mitochondria and elevated mitophagy. UBQLN1 maintains mitochondria and telomeres by regulating proteostasis and plays critical role in neuro-ectoderm differentiation.

Keyphrases

embryonic stem cells
cell death
endoplasmic reticulum
reactive oxygen species
endothelial cells
nlrp inflammasome