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Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis.

Sven Kleine BardenhorstEmanuele CeredaMarco SevergniniMichela BarichellaGianni PezzoliAli KeshavarzianAlessandro DesideriDaniele PietrucciVelma T E AhoFilip ScheperjansFalk HildebrandSeverin WeisMarkus EgertAndré KarchMarius VitalNicole Rübsamen
Published in: European journal of neurology (2023)
Our study summarizes evidence that reduced levels of butyrate-producing taxa in combination with possible degradation of the mucus layer by Akkermansia may promote intestinal inflammation and reduced permeability of the gut mucosal layer. This may allow potentially pathogenic metabolites to transit and enter the enteric nervous system.
Keyphrases
  • parkinson disease
  • deep brain stimulation
  • oxidative stress
  • ms ms
  • endothelial cells
  • ulcerative colitis