Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome.
Yaseen M ArabiYasser MandourahFahad Al-HameedAnees A SindiGhaleb A AlmekhlafiMohamed A HusseinJesna JoseRuxandra PintoAwad Al-OmariAyman KharabaAbdullah AlmotairiKasim Al KhatibBasem AlraddadiSarah ShalhoubAhmed AbdulmomenIsmael QushmaqAhmed MadyOthman SolaimanAbdulsalam M Al-AithanRajaa Al-RaddadiAhmed RagabHanan H BalkhyAbdulrahman Al HarthyAhmad M DeebHanan Al MutairiAbdulaziz Al-DawoodLaura MersonFrederick G HaydenRobert A Fowlernull nullPublished in: American journal of respiratory and critical care medicine (2019)
Corticosteroid therapy in patients with MERS was not associated with a difference in mortality after adjustment for time-varying confounders but was associated with delayed MERS coronavirus RNA clearance. These findings highlight the challenges and importance of adjusting for baseline and time-varying confounders when estimating clinical effects of treatments using observational studies.