Hollow ZnO Nanospheres Enhance Anticancer Immunity by Promoting CD4+ and CD8+ T Cell Populations In Vivo.
Xiupeng WangXia LiAtsuo ItoYu SogoYohei WatanabeNoriko M TsujiPublished in: Small (Weinheim an der Bergstrasse, Germany) (2017)
Appropriate adjuvant aiding in generating robust anticancer immunity is crucial for cancer immunotherapy. Herein, hollow ZnO (HZnO) nanospheres are synthesized by a facile method using carbon nanospheres as the template. The HZnO nanospheres significantly promote the cellular uptake of a model antigen, and cytokine secretion by antigen-presenting cells in vitro. HZnO loaded with ovalbumin and polyinosinic-polycytidylic acid (poly(I:C)) inhibits cancer growth and metastasis to inguinal lymph node in a cancer cell challenge model. Moreover, HZnO loaded with autologous cancer antigens inhibits cancer cell growth in a cancer cell re-challenge model. HZnO nanospheres significantly improve the CD4+ and/or CD8+ T cell population in splenocytes of mice in both cancer cell challenge model and re-challenge model. The HZnO nanospheres can be used for cancer immunotherapy as adjuvant.
Keyphrases
- papillary thyroid
- lymph node
- drug delivery
- early stage
- induced apoptosis
- bone marrow
- immune response
- cell proliferation
- reduced graphene oxide
- stem cells
- radiation therapy
- adipose tissue
- young adults
- cancer therapy
- lymph node metastasis
- mesenchymal stem cells
- wound healing
- mass spectrometry
- radical prostatectomy
- ionic liquid
- high fat diet induced
- allergic rhinitis
- genetic diversity