Pd/NHC-catalyzed cross-coupling reactions of nitroarenes.
Myuto KashiharaRong-Lin ZhongKazuhiko SembaShigeyoshi SakakiYoshiaki NakaoPublished in: Chemical communications (Cambridge, England) (2019)
N-Heterocyclic carbene (NHC) ligands effective for the cross-coupling of nitroarenes were identified. A rational design of the NHC ligand structures enabled significant reduction of catalyst loadings compared with the previous system employing BrettPhos as a phosphine ligand. Experimental and theoretical studies to compare these ligands gave some insights into high activity of the newly developed NHC ligands.