Antiparasitic and anti-inflammatory activities of ß-lapachone-derived naphthoimidazoles in experimental acute Trypanosoma cruzi infection.

Cynthia M CascabulhoMarcelo Meuser-BatistaKelly Cristina G de MouraMaria do Carmo PintoThabata Lopes Alberto DuqueKelly C DemarqueAna Carolina Ramos GuimarãesPedro Paulo de Abreu MansoMarcelo Pelajo-MachadoGabriel M OliveiraSolange L De CastroRubem Figueiredo Sadoko Menna-Barreto

Published in: Memorias do Instituto Oswaldo Cruz (2020)

N1 showed moderate trypanocidal and promising immunomodulatory activities, and its use in combination with benznidazole and/or anti-arrhythmic drugs as well as the efficacy of its alternative formulations must be investigated in the near future.

Keyphrases

trypanosoma cruzi
anti inflammatory
liver failure
drug induced
respiratory failure
high intensity
current status
aortic dissection
mass spectrometry
acute respiratory distress syndrome
extracorporeal membrane oxygenation
high resolution
single molecule