Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation.

Kim E Dzobo Arjen J Cupido Barend M MolLotte C A StiekemaMiranda VerslootMaaike Winkelmeijer Jorge Peter Anne-Marije PennekampStefan HavikFrederic M Vaz Michel van Weeghel Koen H M Prange Johannes H M Levels Menno P J de Winther Sotirios Tsimikas Albert K Groen Erik S G Stroes Dominique P V de Kleijn Jeffrey Kroon

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

Lp(a)-associated DGs and LPA have a potential role in Lp(a)-induced monocyte inflammation by increasing cytokine secretion and monocyte transendothelial migration. This DG-induced inflammation is, in part, NLRP3 inflammasome dependent.

Keyphrases

oxidative stress
nlrp inflammasome
diabetic rats
dendritic cells
high glucose
endothelial cells
peripheral blood
drug induced
immune response