PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer.
Andrea CercekMelissa A LumishJenna SinopoliJill WeissJinru ShiaMichelle Lamendola-EsselImane H El DikaNeil SegalMarina ShcherbaRyan SugarmanZsofia StadlerRona YaegerJ Joshua SmithBenoit RousseauGuillem ArgilesMiteshkumar PatelAvni DesaiLeonard B SaltzMaria WidmarKrishna IyerJanie ZhangNicole GianinoChristopher CranePaul B RomesserEmmanouil P PappouPhilip PatyJulio Garcia-AguilarMithat GonenMarc GollubMartin R WeiserKurt A SchalperLuis A DiazPublished in: The New England journal of medicine (2022)
Mismatch repair-deficient, locally advanced rectal cancer was highly sensitive to single-agent PD-1 blockade. Longer follow-up is needed to assess the duration of response. (Funded by the Simon and Eve Colin Foundation and others; ClinicalTrials.gov number, NCT04165772.).