Hydrogen peroxide (H 2 O 2 ) represents a chemically significant oxidant that is prized for its diverse applicability across various industrial domains. Recent innovations have shed light on the electrosynthesis of H 2 O 2 through two-electron oxygen reduction reactions (2e - ORR) or two-electron water oxidation reactions (2e - WOR), processes that underscore the attractive possibility for the on-site production of this indispensable oxidizing agent. However, the translation of these methods into practical utilization within chemical manufacturing industries remains an aspiration rather than a realized goal. This Perspective intends to furnish a comprehensive overview of the latest advancements in the domain of coupled chemical reactions with H 2 O 2 , critically examining emergent strategies that may pave the way for the development of new reaction pathways. These pathways could enable applications that hinge on the availability and reactivity of H 2 O 2 , including, but not limited to the chemical synthesis coupled with H 2 O 2 and waste water treatment byFenton-like reactions. Concurrently, the Perspective acknowledges and elucidates some of the salient challenges and opportunities inherent in the coupling of electrochemically generated H 2 O 2 , thereby providing a scholarly analysis that might guide future research.