Evoked mid-frontal activity predicts cognitive dysfunction in Parkinson's disease.

Arun SinghRachel C ColeArturo I EspinozaJan R WesselJames F CavanaghNandakumar S Narayanan

Published in: Journal of neurology, neurosurgery, and psychiatry (2023)

These data demonstrate that cue-evoked mid-frontal delta/theta rhythms directly relate to cognition in PD. Our results provide insight into the nature of low-frequency frontal rhythms and suggest that PD-related cognitive dysfunction results from decreased delta/theta activity. These findings could facilitate the development of new biomarkers and targeted therapies for cognitive symptoms of PD.

Keyphrases

working memory
functional connectivity
transcranial magnetic stimulation
big data
electronic health record
physical activity
high frequency
sleep quality
multiple sclerosis
depressive symptoms
machine learning