Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer.
Mustafa Emre GedikOzge SaatciNathaniel OberholtzerMeral UnerOzge Akbulut-CaliskanMetin CetinMertkaya ArasKubra IbisBurcu ÇalışkanErden BanogluStefan WiemannAysegül UnerSercan AksoyShikhar MehrotraÖzgür SahinPublished in: Cancer research (2024)
Loss of induction of immunogenic cell death in response to T-DM1 leads to resistance that can be overcome by targeting TACC3, providing an attractive strategy to improve the efficacy of T-DM1.