An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin.

Liat Peretz ZatsLabiba AhmadNatania CasdenMeelim J LeeVitali BelzerOrit AdatoShaked Bar CohenSeung-Hyun B KoMariella G FilbinRon UngerDouglas A LauffenburgerRosalind A SegalOded Behar

Published in: Neuro-oncology advances (2022)

Crosstalk between DIPGs and the brainstem microenvironment, in particular microglia, through IL33 and other secreted factors, modulates spatiotemporal patterning of this HGG and could prove to be an important future therapeutic target.

Keyphrases

high grade
low grade
inflammatory response
neuropathic pain
stem cells
current status
spinal cord injury
spinal cord