A CMOS NMR needle for probing brain physiology with high spatial and temporal resolution.
Jonas HandwerkerMarlon Pérez-RodasMichael BeyerleinFranck VincentArmin BeckNicolas FreytagXin YuRolf PohmannJens AndersKlaus SchefflerPublished in: Nature methods (2019)
Magnetic resonance imaging and spectroscopy are versatile methods for probing brain physiology, but their intrinsically low sensitivity limits the achievable spatial and temporal resolution. Here, we introduce a monolithically integrated NMR-on-a-chip needle that combines an ultra-sensitive 300 µm NMR coil with a complete NMR transceiver, enabling in vivo measurements of blood oxygenation and flow in nanoliter volumes at a sampling rate of 200 Hz.
Keyphrases
- high resolution
- solid state
- single molecule
- magnetic resonance
- magnetic resonance imaging
- ultrasound guided
- white matter
- resting state
- computed tomography
- molecular dynamics simulations
- mass spectrometry
- functional connectivity
- contrast enhanced
- circulating tumor cells
- high throughput
- multiple sclerosis
- subarachnoid hemorrhage