Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases.

Jean Claude Semuto NgabonzizaTom DecrooRodrigue ManilihoYves M HabimanaArmand Van DeunBouke C de Jong

Published in: Open forum infectious diseases (2021)

We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

Keyphrases

pulmonary tuberculosis
mycobacterium tuberculosis
machine learning
small molecule
deep learning
high throughput
single molecule
fluorescence imaging
human immunodeficiency virus
hepatitis c virus
hiv infected
hiv aids