Endothelial K Ca 3.1 and K Ca 2.3 Mediate S1P (Sphingosine-1-Phosphate)-Dependent Vasodilation and Blood Pressure Homeostasis.
Jing-Jing LiXin-Yi ZhaoYan WangRui XuXiao-Hui DiYu ZhangHongyan YangMeng-Zhuan HanRu-Yue BaiLin XieZheng-Da PangXing ZhangJianbao ZhangXiao-Jun DuXiu-Ling DengYi ZhangWenjun XiePublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
3.1-activated endothelium-dependent hyperpolarization in vasodilation and blood pressure homeostasis in response to S1P. This mechanistic demonstration would facilitate the development of new therapies for cardiovascular diseases associated with hypertension.